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Related Concept Videos

Salivary Glands and Saliva01:23

Salivary Glands and Saliva

The salivary glands, of which there are three pairs known as the parotid, submandibular, and sublingual glands, play a crucial role in maintaining oral health and initiating the digestive process. Positioned near the ears, beneath the masseter muscle, the parotid glands secrete saliva into the oral cavity through the parotid duct of Stensen. Meanwhile, the submandibular glands, located on the floor of the mouth, secrete saliva through channels named submandibular ducts. The sublingual glands,...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Exocrine Glands: Methods of Secretion01:08

Exocrine Glands: Methods of Secretion

Exocrine glands are those that release their secretions through ducts. Based on their mode of secretion, they can be classified into merocrine, apocrine, and holocrine.
Merocrine Secretion
Merocrine secretion is the most common type of exocrine secretion. The secretions are enclosed in vesicles and moved to the cell's apical surface, where the contents are released by exocytosis. For example, mucous, a watery secretion rich in the glycoprotein mucin, is a merocrine secretion. The eccrine glands...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...

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Related Experiment Video

Updated: Jun 13, 2026

Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging
05:40

Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging

Published on: November 17, 2023

Salivary gland regeneration.

Guy H Carpenter, Emanuele Cotroneo

    Frontiers of Oral Biology
    |April 30, 2010
    PubMed
    Summary
    This summary is machine-generated.

    Animal salivary gland regeneration offers hope for human salivary gland repair. Regeneration processes mimic embryonic development, revealing key gene signaling pathways and the potential role of stem cells.

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    Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
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    Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

    Published on: May 17, 2019

    Isolation of Mouse Salivary Gland Stem Cells
    09:52

    Isolation of Mouse Salivary Gland Stem Cells

    Published on: February 8, 2011

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    Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging
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    Interrogating Cell-Cell Interactions in the Salivary Gland via Ex Vivo Live Cell Imaging

    Published on: November 17, 2023

    Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics
    07:38

    Radiation Treatment of Organotypic Cultures from Submandibular and Parotid Salivary Glands Models Key In Vivo Characteristics

    Published on: May 17, 2019

    Isolation of Mouse Salivary Gland Stem Cells
    09:52

    Isolation of Mouse Salivary Gland Stem Cells

    Published on: February 8, 2011

    Area of Science:

    • Regenerative medicine
    • Developmental biology
    • Salivary gland biology

    Background:

    • Animal salivary glands can recover from induced atrophy, suggesting potential for human salivary gland regeneration after injury.
    • Regeneration mechanisms in animal models resemble embryonic salivary gland formation.
    • Secretory proteins in regenerated cells match those in perinatal glands.

    Purpose of the Study:

    • To investigate the mechanisms of salivary gland regeneration in animal models.
    • To identify key molecular pathways involved in early-stage glandular regeneration.
    • To explore the role of stem cells in salivary gland regeneration.

    Main Methods:

    • Induction of an atrophic state in animal salivary glands.
    • Analysis of regenerated acinar and ductal cell secretory proteins.
    • Microarray analysis to identify global gene expression changes.
    • Bioinformatic techniques to analyze signaling cascades.

    Main Results:

    • Regenerated salivary glands exhibit secretory proteins identical to perinatal glands.
    • Microarray and bioinformatics identified crucial signaling cascades in early regeneration.
    • Regeneration processes mirror embryonic salivary gland development.

    Conclusions:

    • Animal salivary gland regeneration provides a model for potential human salivary gland regeneration.
    • Key signaling pathways and stem cell involvement are critical for glandular regeneration.
    • Further research is needed for stem cell isolation and differentiation into functional salivary glands.