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Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives
Wei-Ming Zhou1, Rong-Rong He, Jian-Tao Ye
1School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China. weiming81@126.com
Molecules (Basel, Switzerland)
|April 30, 2010
Abstract:
This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.

