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Changes in plasma atrial natriuretic peptide after angiocardiography
12nd Department of Internal Medicine, Yamanashi Medical University, Yamanashi, Japan.
Insights
Patients with high baseline atrial natriuretic peptide (ANP) levels showed no increase after angiocardiography. This suggests their ANP secretion may already be maximally activated or less sensitive to the procedure.
Area of Science:
- Cardiology
- Endocrinology
- Medical Diagnostics
Background:
- Angiocardiography is a key diagnostic tool for heart conditions.
- Plasma atrial natriuretic peptide (ANP) levels typically rise post-contrast injection.
- Elevated baseline ANP is common in heart failure, hypertension, and hypertrophy, but its response to angiography is unclear.
Purpose of the Study:
- To determine if plasma ANP concentrations change after angiocardiography in patients with elevated baseline ANP.
- To compare ANP response to angiography between patients with normal and high baseline ANP levels.
Main Methods:
- Measured plasma ANP in 32 angina pectoris patients before and after angiocardiography.
- Grouped patients based on pre-angiography ANP concentrations (normal vs. high).
Main Results:
- Patients with normal baseline ANP showed a significant increase post-angiography.
- Patients with high baseline ANP exhibited no significant change in ANP levels after the procedure.
Conclusions:
- The lack of ANP increase in patients with high baseline levels may indicate reduced sensitivity to the angiographic stimulus.
- Alternatively, maximal ANP secretion may already be present at rest in these individuals.
Background:
Angiocardiography is an important diagnostic modality for evaluation of heart disease. It is well known that the concentration of plasma atrial natriuretic peptide (ANP) increases after injection of contrast medium. On the other hand, some patients with hypertension, heart failure or cardiac hypertrophy have an increased plasma ANP concentration at baseline; however, whether ANP increases after angiography in these patients is unknown.
Objectives:
To investigate changes in plasma ANP concentrations after angiocardiography in patients with high ANP concentrations at baseline.
Patients And Methods:
Plasma ANP concentrations of 32 patients with angina pectoris were measured before and after angiocardiography. They were then classified into two groups according to their ANP concentration before examination.
Results:
ANP concentration after the injection of contrast medium increased significantly in patients with normal ANP concentrations before angiography but did not change in patients with high ANP concentrations at rest.
Conclusions:
These results suggest that the absence of an increase in ANP after angiography may in part be due to reduced sensitivity to the angiography stimulus or to an already maximal activation of ANP secretion at baseline.
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