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Micelles

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

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Updated: Jun 13, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Thermosensitive micelles from PEG-based ether-anhydride triblock copolymers.

Aijun Zhao¹, Shaobing Zhou, Qi Zhou

¹Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, 610031, People's Republic of China.

Pharmaceutical Research

|April 30, 2010

Summary

Thermosensitive micelles fabricated from poly(ethylene glycol) (PEG), 1,3-bis(carboxyphenoxy) propane (CPP), and sebacic acid (SA) demonstrate potential as drug carriers. These biocompatible nanocarriers exhibit temperature-dependent sol-gel transitions and sustained drug release, maintaining anti-tumor efficacy.

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Last Updated: Jun 13, 2026

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer Micelles Stabilized by π-π Stacking Interactions

Published on: October 10, 2016

Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

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Published on: August 28, 2015

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Published on: December 23, 2016

Area of Science:

Polymer Chemistry
Materials Science
Nanomedicine

Background:

Development of novel drug delivery systems is crucial for improving therapeutic efficacy.
Polymer-based micelles offer versatile platforms for encapsulating and delivering therapeutic agents.
Thermosensitive polymers enable stimuli-responsive drug release, enhancing targeted delivery.

Purpose of the Study:

Fabrication of thermosensitive micelles using a poly(PEG:CPP:SA) terpolymer for drug delivery.
Investigation of the self-assembly, sol-gel transition, and drug release characteristics of these micelles.
Evaluation of the biocompatibility and anti-tumor efficacy of the drug-loaded micelles.

Main Methods:

Terpolymer synthesis and micelle self-assembly via precipitation technology.
Sol-gel transition analysis using tube-tilting and dynamic rheology.
In vitro drug release studies in phosphate-buffered solution (PBS) at varying temperatures (25, 37, 45°C).
In vitro cytotoxicity and tumor cell growth inhibition assays.

Main Results:

Micelle diameter increased with temperature and CPP/SA chain length.
Low-concentration micelles showed sol-to-nanogel transition near body temperature; high-concentration solutions exhibited sol-to-gel transition over a wider temperature range (20-70°C).
Drug release exhibited an initial burst followed by sustained release.
Terpolymer micelles demonstrated biocompatibility, and encapsulated doxorubicin.HCl retained its anti-tumor activity.

Conclusions:

The poly(PEG:CPP:SA) terpolymer micelles are promising drug carriers.
These micelles show potential for nanomedicine applications due to their thermosensitive and drug-releasing properties.
The ether-anhydride polymer family holds significant promise for novel drug delivery systems.