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Updated: Jun 13, 2026

In Vitro Differentiation of Human CD4+FOXP3+ Induced Regulatory T Cells (iTregs) from Naïve CD4+ T Cells Using a TGF-β-containing Protocol
Published on: December 30, 2016
Regulatory T-cells, FoxP3 and atherosclerosis
Michal Entin-Meer1, Arnon Afek, Jacob George
1Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Regulatory T-cells (Treg) are crucial in managing immune responses and preventing autoimmune diseases. This study explores their role in atherosclerosis, investigating how Treg influence plaque development and stability.
Area of Science:
- Immunology
- Cardiovascular Research
- Atherosclerosis
Background:
- Innate immune responses and modified lipid accumulation drive atherosclerotic plaque progression.
- Regulatory T-cells (Treg), specifically CD4+CD25+ FoxP3+ cells, are key in maintaining immunologic self-tolerance.
- Evidence from human and murine studies suggests Treg involvement in atherosclerosis initiation and plaque instability.
Purpose of the Study:
- To summarize experimental approaches for studying Treg mechanisms in atherosclerosis.
- To investigate the potential clinical benefits of Treg in stabilizing atherosclerotic plaques.
Main Methods:
- Review of experimental methodologies used to study Treg in atherosclerosis.
- Analysis of data from human and murine models.
Main Results:
- Treg play a significant role in the initiation and progression of atherosclerotic lesions.
- Treg influence the stability of atherosclerotic plaques, impacting ischemic events.
Conclusions:
- Understanding Treg mechanisms is vital for developing new atherosclerosis therapies.
- Treg hold promise for stabilizing atherosclerotic plaques and preventing cardiovascular events.
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