Deleted in breast cancer 1 (DBC1) is a dynamically regulated protein

Related Experiment Video

Updated: Jun 13, 2026

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
07:41

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

Published on: May 17, 2019

J E Kim1, S Sung

  • 1Department of Pharmacology, Kyung Hee University, School of Medicine, Dongdaemun-gu, Seoul, Republic of Korea. jekim@khu.ac.kr

Neoplasma
|May 1, 2010
PubMed

Insights

Deleted in breast cancer 1 (DBC1) protein self-associates and changes during the cell cycle. DBC1 is upregulated in lung cancer, suggesting its potential as a cancer diagnostic marker.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Cell Biology

Background:

  • Deleted in breast cancer 1 (DBC1) is a novel protein implicated in tumorigenesis.
  • DBC1 regulates key proteins like SIRT1, ERalpha, RARalpha, and AR, but its molecular characteristics are poorly understood.
  • Understanding DBC1's molecular behavior is crucial for elucidating its role in cancer development.

Purpose of the Study:

  • To investigate the molecular characteristics of DBC1, focusing on its oligomerization and cell cycle-dependent expression.
  • To explore the differential expression of DBC1 in normal versus cancer cells.
  • To assess the potential of DBC1 as a diagnostic marker for cancers.

Main Methods:

  • Analysis of DBC1 homo-oligomerization.
  • Observation of DBC1 expression patterns throughout the cell cycle.
  • Comparison of DBC1 protein levels and recognition by antibodies in normal lung fibroblasts versus lung and breast cancer cells.

Main Results:

  • DBC1 was found to homo-oligomerize.
  • DBC1 exhibits dynamic expression changes during the cell cycle.
  • DBC1 expression is elevated in lung cancer cells compared to normal lung fibroblasts, with distinct protein forms recognized in cancer versus normal cells.

Conclusions:

  • Further study of DBC1 oligomerization and cell cycle dynamics will clarify its functional mechanisms.
  • The differential expression of DBC1 between normal and cancer cells supports its potential utility.
  • DBC1 holds promise as a diagnostic marker for various cancers.

More Related Videos

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells09:24

Silencing of BRCA2 to Identify Novel BRCA2-regulated Biological Functions in Cultured Human Cells

Published on: August 12, 2015

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins10:24

Two- and Three-Dimensional Live Cell Imaging of DNA Damage Response Proteins

Published on: September 28, 2012

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
Positive Regulator Molecules02:39

Positive Regulator Molecules

Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
Positive Regulator Molecules01:45

Positive Regulator Molecules

To consistently produce healthy cells, the cell cycle—the process that generates daughter cells—must be precisely regulated.