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Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
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The association between ALS and population density: A population based study.

Kirsten M Scott1, Kumar Abhinav, Lokesh Wijesekera

  • 1King's College Hospital, London, UK.

Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
|May 1, 2010
PubMed
Summary
This summary is machine-generated.

Amyotrophic lateral sclerosis (ALS) incidence was studied in Southeast England. This research found that people diagnosed with ALS were more likely to live in densely populated areas.

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Area of Science:

  • Neurology
  • Epidemiology

Background:

  • Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease.
  • Previous research on the association between rural residence and ALS incidence has yielded conflicting results.

Purpose of the Study:

  • To investigate the association between rural versus urban residence and ALS in Southeast England.
  • To determine if population density correlates with ALS incidence in this region.

Main Methods:

  • Utilized the South-East England ALS Register (1995-2005) for incident cases.
  • Classified residential areas by population density (London boroughs, non-metropolitan districts).
  • Calculated age- and sex-adjusted ALS incidence rates per region and tested for correlation with population density using linear regression.

Main Results:

  • Population density at diagnosis explained 25% of the variance in ALS rates (r = 0.5, p < 0.01).
  • Individuals diagnosed with ALS in this cohort were more frequently residents of high population density areas.

Conclusions:

  • Residence in high population density areas is associated with a higher incidence of ALS in Southeast England.
  • Findings suggest a potential environmental or lifestyle factor linked to urban living that may influence ALS risk.