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Polymorphisms in DNA damage response genes and head and neck cancer risk
Rafael E Flores-Obando1, Susanne M Gollin, Camille C Ragin
1Department of Epidemiology, State University of New York Downstate Medical Center, NY, USA.
Background:
Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results.
Objective:
To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk.
Method:
A meta-analysis including 30 case-control studies was performed.
Results:
Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.
Conclusion:
Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.
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