Plasma adiponectin concentration and insulin resistance: role of successful kidney transplantation

Adiponectin (ADPN) has been reported to be inversely correlated with insulin resistance (IR) in uremic subjects and following kidney transplantation. Kidneys have been suggested to play a part in ADPN clearance. This study sought to evaluate this hypothesis. We enrolled 67 candidates with end-stage renal disease (ESRD) along with 30 healthy unrelated donors. Plasma ADPN, IR (based on the homeostasis model assessment for IR index), and glomerular filtration rates were compared between control and patient groups. The correlations of the aforementioned variables were also compared in the patient group 1 day before and 14 days following transplantation. The changes in measured parameters were also compared with control group values. The glomerular filtration rate was significantly decreased among recipients. ADPN levels were remarkably higher in the patient group before transplantation when compared with healthy subjects (P<.001) and remained significantly higher thereafter (P<.001). Insulin resistance was higher, albeit not significantly, among ESRD patients compared with controls (P>.05) and it increased following transplantation (P=.03). There was no correlation between ADPN, IR, and glomerular filtration rate in normal individuals or ESRD patients before or after transplantation. It is our assumption that mechanisms other than kidney function are probably involved in ADPN metabolism in ESRD patients and in the immediate phase following transplantation. It does not seem that ADPN substantially affects IR either in ESRD or transplantation patients.