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Updated: Jun 13, 2026
05:23
Investigating Migraine-Like Behavior Using Light Aversion in Mice
Published on: August 11, 2021
CGRP receptor antagonism and migraine
1Department of Medicine, Institute of Clinical Sciences, Lund University Hospital, Lund University, 22185 Lund, Sweden. lars.edvinsson@med.lu.se
Summary
Calcitonin gene-related peptide (CGRP) plays a key role in pain and blood vessel dilation. CGRP receptor antagonists show promise in treating migraine by blocking pain signals.
Area of Science:
- Neuroscience
- Pharmacology
Background:
- Calcitonin gene-related peptide (CGRP) is widely distributed in the nervous system.
- It is involved in functions including pain, vasodilation, and motor control.
- Alpha-CGRP is found in sensory neurons, while beta-CGRP is prevalent in the enteric nervous system.
Purpose of the Study:
- To review the role of CGRP in the nervous system.
- To discuss the involvement of CGRP in migraine pathophysiology.
- To highlight the therapeutic potential of CGRP receptor antagonists.
Main Methods:
- Review of existing literature on CGRP distribution and function.
- Analysis of CGRP's role in trigeminovascular pathways.
- Examination of clinical data on CGRP receptor antagonists for migraine.
Main Results:
- CGRP is released from trigeminal nerves during migraine attacks.
- It causes vasodilation and contributes to pain signaling.
- CGRP receptor antagonists effectively abort acute migraine attacks.
Conclusions:
- CGRP is a critical mediator in the trigeminovascular system.
- Targeting the CGRP pathway offers a promising therapeutic strategy for migraine.
- CGRP receptor antagonists represent a significant advancement in migraine treatment.
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