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BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.

G Spalletta¹, D W Morris, F Angelucci

¹IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy.

European Psychiatry : the Journal of the Association of European Psychiatrists

|May 1, 2010

Summary

Genetic variations in brain-derived neurotrophic factor (BDNF) may impact behavior. This study found that the BDNF Met allele is linked to increased aggressive behavior in individuals with schizophrenia.

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Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Brain-derived neurotrophic factor (BDNF) plays a crucial role in neuronal plasticity and survival.
Gene variants, such as the BDNF Val66Met polymorphism, are investigated for their potential influence on human behavior.

Purpose of the Study:

To examine the association between the BDNF Val66Met polymorphism and aggressive behavior.
To understand the genetic underpinnings of behavioral traits in schizophrenia patients.

Main Methods:

Genotyping of the BDNF Val66Met polymorphism in a cohort of schizophrenic patients.
Assessment of aggressive behavior within the study population.

Main Results:

A positive correlation was observed between the number of BDNF Met alleles and the level of aggressive behavior.
The presence of the BDNF Met allele may be a risk factor for heightened aggression in schizophrenia.

Conclusions:

The BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.
BDNF gene variants represent a potential biological marker for understanding behavioral variations in psychiatric disorders.