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Updated: Jun 13, 2026

3D Modeling of Dendritic Spines with Synaptic Plasticity
Published on: May 18, 2020
Mechanisms of translational regulation in synaptic plasticity
Wayne S Sossin1, Jean-Claude Lacaille
1Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada. Wayne.sossin@mcgill.ca
Abstract:
The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mechanisms by which neurons regulate translation during synaptic plasticity. Particular focus will be on the different transduction mechanisms that selectively target distinct elements of the mRNA in the regulation of translation during plasticity.
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