Attenuation of exercise induced ST elevation in non-obstructive coronary disease--a case for calcium channel
1Department of Cardiology, Western Infirmary, Glasgow G11 6NT, Scotland. colinjamespetrie@yahoo.co.uk
Insights
A patient with chest pain experienced exercise-induced ST elevation, a sign of heart issues. Diltiazem treatment resolved this, indicating its effectiveness for managing such cardiac events.
Area of Science:
- Cardiology
- Clinical Medicine
- Pharmacology
Background:
- Atenolol therapy is common for cardiovascular conditions.
- Smokers present unique challenges in cardiovascular disease management.
- Exercise-induced ST segment elevation requires careful diagnosis.
Observation:
- A male smoker on atenolol therapy presented with chest pain.
- Dramatic exercise-induced ST segment elevation was observed.
- Coronary angiography revealed non-obstructive coronary artery disease.
Findings:
- Treatment with diltiazem effectively abolished exercise-induced ST segment elevation.
- Non-obstructive coronary artery disease was identified as the underlying factor.
- Diltiazem proved effective in managing ST segment elevation in this patient.
Implications:
- Diltiazem may be a viable treatment option for managing exercise-induced ST segment elevation in select patients.
- This case highlights the importance of considering non-obstructive causes of ischemic symptoms.
- Further research into diltiazem's role in managing vasospastic angina is warranted.
Abstract:
A male smoker already on atenolol therapy, presented with chest pain and dramatic exercise induced ST segment elevation. Coronary angiography demonstrated non-obstructive disease and treatment with diltiazem abolished ST segment elevation on subsequent exercise testing.
Related Concept Videos
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Antihypertensive Drugs: Action of Calcium Channel Blockers
Coronary Artery Disease V: Interprofessional Care
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
Acute Coronary Syndrome I: Introduction
Antiarrhythmic Drugs: Class IV Agents as Calcium Channel Blockers
Verapamil, a calcium channel blocker, inhibits calcium movement across myocardial cell membranes and vascular smooth muscle. This results in the dilation of coronary and...


