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Published on: June 2, 2014
Migraine with aura is a risk factor for cervical artery dissection: a case-control study
V Artto1, T M Metso, A J Metso
1Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland. ville.artto@hus.fi
Cerebrovascular Diseases (Basel, Switzerland)
|May 1, 2010
Summary
Cervical artery dissection (CAD) is strongly linked to migraine, a common stroke risk factor in young adults. Interestingly, CAD may alleviate migraine symptoms in many patients.
Area of Science:
- Neurology
- Vascular Medicine
- Genetics
Background:
- Cervical artery dissection (CAD) is a leading cause of stroke in young adults.
- Migraine, particularly with aura (MA), is a known risk factor for ischemic stroke.
- Previous studies suggest an association between CAD and migraine, but large-scale data are lacking.
Purpose of the Study:
- To investigate the lifetime prevalence of migraine in patients with CAD compared to healthy controls.
- To analyze migraine characteristics and CAD subtypes for potential shared genetic or pathophysiological backgrounds.
- To explore the impact of CAD on migraine activity.
Main Methods:
- A case-control study involving 313 patients with CAD and 313 matched healthy controls.
- Comparison of lifetime migraine prevalence and characteristics between groups.
- Analysis of clinical and radiological features of CAD in relation to migraine subtypes.
Main Results:
- Migraine prevalence was significantly higher in CAD patients (36%) than in controls (23%), with a notable association for migraine with aura (MA) (23% vs. 12%).
- This association remained significant across both sexes.
- Over 60% of CAD patients with active migraine at the time of dissection reported subsequent alleviation of migraine symptoms.
Conclusions:
- CAD patients represent a significant link between ischemic stroke and migraine.
- A common pathophysiological or genetic background may underlie both conditions.
- CAD occurrence appears to lead to a reduction in migraine activity.
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