Related Experiment Video
Updated: Jun 13, 2026
09:23
Successful Orthotopic Liver Transplantation in Mice Utilizing Microcomputed Tomography Angiography
Published on: September 22, 2023
Liver transplantation
1Hepatobiliary Surgery and Liver Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Gut and Liver
|May 1, 2010
Summary
Living-donor liver transplantation (LDLT) is crucial in East Asia due to organ shortages. LDLT offers comparable outcomes to deceased-donor liver transplantation (DDLT) for severe liver disease, but long-term complications require monitoring.
Area of Science:
- Hepatology
- Transplant Surgery
- Gastroenterology
Background:
- Liver transplantation is a vital treatment for end-stage liver disease and acute liver failure.
- Organ shortages, especially from deceased donors in East Asia, necessitate alternatives like living-donor liver transplantation (LDLT).
Purpose of the Study:
- To provide an updated review of liver transplantation, focusing on adult recipients.
- To highlight recent advancements in indications, patient selection, surgical techniques, immunosuppression, and long-term management for LDLT and deceased-donor liver transplantation (DDLT).
Main Methods:
- This is a review article synthesizing current knowledge on liver transplantation.
- It compares aspects of LDLT and DDLT, including donor/recipient operations and outcomes.
Main Results:
- LDLT indications mirror DDLT criteria, with technical improvements enhancing its application.
- Experienced centers achieve comparable outcomes for high-MELD score and acute-on-chronic liver failure patients undergoing LDLT versus DDLT.
- Timely transplantation with quality grafts is achievable through LDLT.
Conclusions:
- LDLT is a viable and effective alternative to DDLT, particularly in regions with organ scarcity.
- Long-term management of liver transplant recipients must address complications like renal failure, metabolic disorders, and de novo tumors, often linked to immunosuppression.
Related Concept Videos
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
01:26Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
01:24Tissue Transplantation
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
01:24Liver Regeneration
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are large...