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DNA single strand-breaks in lymphocytes after metronidazole therapy
1Department of Physiological Chemistry, University of Mainz, Fed. Rep. of Germany.
Arzneimittel-Forschung
|February 1, 1991
Abstract:
DNA single strand-breaks were examined in lymphocytes of patients treated with metronidazole (CAS 443-48-1) for trichomonas vaginalis infection before, on day one, and day seven of treatment. Recommended dosage of metronidazole induces DNA single strand-breaks. Single strand-breaks were repaired after therapy. No irreversible DNA damage remains. The DNA repair mechanisms are genetically determined. Therefore a mutagenic effect of metronidazole must be discussed in patients with DNA repair defects.