Chronic inflammatory diseases of the bowel: diagnosis and follow-up

Guillaume Gorincour1, Audrey Aschero, Catherine Desvignes

  • 1Department of Pediatric Radiology, Hôpital Timone Enfant, 264 rue Saint Pierre, Marseille Cedex 5, France.

Insights

Pediatric inflammatory bowel disease (IBD) often presents severely. While ultrasound is a first-line imaging choice, advances in MR enterography offer reproducible data for evaluating new therapies in pediatric IBD.

Area of Science:

  • Pediatric gastroenterology
  • Medical imaging
  • Radiology

Background:

  • Approximately 25% of inflammatory bowel disease (IBD) cases occur in children, who are more likely to experience severe disease at diagnosis.
  • Current imaging modalities for pediatric IBD have limitations in terms of complexity and cost.

Purpose of the Study:

  • To evaluate the role of Magnetic Resonance (MR) enterography in diagnosing and managing pediatric inflammatory bowel disease.
  • To highlight the potential of MR enterography as a gold standard for assessing new therapies.

Main Methods:

  • Review of existing literature on imaging techniques for pediatric IBD.
  • Discussion of the technical advancements and benefits of MR enterography.
  • Comparison of MR enterography with other imaging modalities like ultrasound (US).

Main Results:

  • Ultrasound (US) is often considered the initial imaging examination for unknown pediatric IBD diagnoses.
  • MR enterography offers reproducible data crucial for evaluating treatment efficacy.
  • Technical progress is enhancing the utility and adoption of MR enterography.

Conclusions:

  • MR enterography's role in pediatric IBD management is expected to grow due to technical advancements and its suitability for evaluating new therapies.
  • While US is valuable, MR enterography provides a gold standard for assessing treatment response in pediatric IBD.

Related Concept Videos

Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...