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Hypertension in glucose intolerance and diabetes

R J Jarrett1

  • 1Department of Public Health Medicine, United Medical School, Guy's Hospital, London, UK.

Journal of Internal Medicine. Supplement
|January 1, 1991
PubMed

Insights

High blood pressure and albuminuria are common in insulin-dependent diabetes. The relationship between these conditions in non-insulin-dependent diabetes is less clear and independent of obesity.

Area of Science:

  • Nephrology
  • Endocrinology
  • Cardiovascular Medicine

Background:

  • Raised blood pressure and increased urinary albumin excretion are frequently observed together in insulin-dependent diabetes mellitus.
  • The causal relationship between hypertension and renal dysfunction in diabetes remains unclear.
  • In non-insulin-dependent diabetes mellitus, hypertension is less consistently associated with obesity, but present in glucose-intolerant individuals.

Purpose of the Study:

  • To investigate the association between raised blood pressure and urinary albumin excretion in different types of diabetes mellitus.
  • To clarify the interplay between hypertension, albuminuria, and obesity in diabetes management.

Main Methods:

  • Observational study analyzing blood pressure and urinary albumin excretion data.
  • Statistical analysis to adjust for confounding factors like obesity and glucose intolerance.
  • Comparison of findings between insulin-dependent and non-insulin-dependent diabetes mellitus.

Main Results:

  • A strong association between raised blood pressure and increased urinary albumin excretion was noted in insulin-dependent diabetes mellitus.
  • In non-insulin-dependent diabetes mellitus, hypertension was not significantly linked to obesity but was present in glucose-intolerant individuals.
  • Inconsistent associations were reported for albumin excretion and blood pressure in non-insulin-dependent diabetes.

Conclusions:

  • The co-occurrence of hypertension and albuminuria in insulin-dependent diabetes warrants further investigation into their causal links.
  • Hypertension in non-insulin-dependent diabetes is linked to glucose intolerance, independent of obesity.
  • Further research is needed to understand the inconsistent associations in non-insulin-dependent diabetes.

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