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Evolving central hypothyroidism in children with optic nerve hypoplasia
Nina S Ma1, Cassandra Fink, Mitchell E Geffner
1Division of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Childrens Hospital Los Angeles and Keck School of Medicine of the University of Southern California, USA. nina.ma@childrens.harvard.edu
Background:
Children with optic nerve hypoplasia (ONH) are at high risk for early-onset congenital central hypothyroidism (CH); however, reports of evolving, late-onset CH are rare and poorly documented.
Aim:
To examine the clinical and biochemical data of children with ONH who developed CH after documented normal thyroid function tests at an earlier age.
Patients And Methods:
Children who developed late-onset CH were selected for review from an observational study (n = 214) that examined clinical risk factors for endocrinological abnormalities in children with ONH.
Results:
Eight patients with ONH developed CH between the ages of 20-51 months. One child at age 28 months developed CH within 4 months of prior normal thyroid function tests. There were no associations among clinical, neuroradiographical, vision, and/or pituitary outcomes.
Conclusions:
Children with ONH may develop CH over time, and surveillance thyroid function tests may be necessary as frequently as every four months.
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