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Updated: Jun 13, 2026

Murine Isolated Heart Model of Myocardial Stunning Associated with Cardioplegic Arrest
Published on: August 6, 2015
Neurogenic stunned myocardium after acute hydrocephalus
Jeremiah Johnson1, John Ragheb, Ruchira Garg
1Division of Pediatric Neurosurgery, University of Miami Miller School of Medicine, Lois Pope Life Center, 1095 NW 14th Terrace, Miami, Florida 33136, USA. jjohnson22@med.miami.edu
Abstract:
Neurogenic stunned myocardium (NSM) is a syndrome of cardiac stunning after a neurological insult. It is commonly observed after aneurysmal subarachnoid hemorrhage but is increasingly being reported after other neurological events. The underlying mechanism of NSM is believed to be a hypothalamic-mediated sympathetic surge causing weakened cardiac contractility and even direct cardiac myocyte damage. The authors report 2 cases of NSM in pediatric patients after acute hydrocephalus. Both patients experienced severe cardiac dysfunction in the acute phase but ultimately had a good neurological outcome and a full cardiac recovery. The identification, treatment, and outcome in 2 rare pediatric cases of NSM are discussed, and the history of the brain-cardiac connection is reviewed.
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