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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

Microfluidic platforms for single-cell analysis.

Richard N Zare¹, Samuel Kim

¹Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. zare@stanford.edu

Annual Review of Biomedical Engineering

|May 4, 2010

Summary

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Microfluidics enables advanced single-cell chemical analysis by integrating complex procedures into small devices. This technology offers rapid, accurate, and cost-effective tools for analyzing intracellular components in single cells.

Area of Science:

Biotechnology
Analytical Chemistry
Cell Biology

Background:

Microfluidics is crucial for single-cell chemical analysis.
Microfabricated devices integrate complex chemical cytometry procedures.
Picoliter fluid handling enables precise cell manipulation and analysis.

Purpose of the Study:

To provide an overview of microfluidic technology advancements for single-cell chemical analysis.
To highlight the capabilities of microfluidics in quantitative intracellular component analysis.
To showcase the benefits of microfluidic approaches in single-cell biology.

Main Methods:

Integration of complex chemical cytometry procedures into microfluidic devices.
Utilizing picoliter fluid handling for cell manipulation, lysis, and reaction control.

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Related Experiment Videos

Last Updated: Jun 13, 2026

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

Published on: October 15, 2013

A Microfluidic Platform for High-throughput Single-cell Isolation and Culture

A Microfluidic Platform for High-throughput Single-cell Isolation and Culture

Published on: June 16, 2016

Fluorescence detection methods for microfluidic droplet platforms

Fluorescence detection methods for microfluidic droplet platforms

Published on: December 10, 2011

Incorporating separation modalities like chromatography and electrophoresis within microchannels.

Main Results:

Demonstrated efficient minimization of sample dilution after cell lysis.
Enabled quantitative analysis of various intracellular components.
Showcased the potential for rapid, accurate, and cost-effective single-cell analysis.

Conclusions:

Microfluidic technology is a powerful tool for single-cell chemical analysis.
Microfluidic devices offer integrated solutions for complex cellular assays.
This approach significantly advances the field of single-cell biology and chemical cytometry.