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The frequency and functional impact of overlapping hypertension on hypertrophic cardiomyopathy: a single-center

Farhan Aslam1, Attiya Haque, Joanne Foody

  • 1Brigham and Women's Hospital, Boston, MA, USA. faslam77@gmail.com

Journal of Clinical Hypertension (Greenwich, Conn.)
|May 4, 2010
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) often coexists with systemic hypertension. Patients with both conditions are older and have increased risks of diabetes, coronary artery disease, and noncardiac death.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex cardiac condition.
  • Systemic hypertension is a common comorbidity in the adult population.

Purpose of the Study:

  • To compare clinical presentation, management, outcomes, and echocardiographic findings in adult HCM patients with and without systemic hypertension.
  • To investigate the impact of coexisting systemic hypertension on HCM patient characteristics and risks.

Main Methods:

  • Retrospective evaluation of 196 adult patients with HCM between 1995 and 2005.
  • Comparison of 122 patients with systemic hypertension (group 1) against 74 patients without (group 2).
  • Analysis of clinical data, comorbidities, and echocardiographic parameters.

Main Results:

  • Patients with HCM and hypertension (group 1) were older at diagnosis.
  • Group 1 showed a higher prevalence of diabetes (28% vs 9%) and coronary artery disease (40% vs 25%).
  • Echocardiography revealed increased systolic anterior motion of the mitral valve (52% vs 19%) and mitral annular calcification (27% vs 13%) in group 1.

Conclusions:

  • Systemic hypertension is a frequent comorbidity in adult HCM patients.
  • The presence of systemic hypertension in HCM is associated with older age, increased risk of diabetes, coronary artery disease, and noncardiac death.
  • Echocardiographic findings like SAM and MAC are more prevalent in hypertensive HCM patients.

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