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Updated: Jun 13, 2026

In Vitro Model of Physiological and Pathological Blood Flow with Application to Investigations of Vascular Cell Remodeling
Published on: November 3, 2015
Variability--the drama of the circulation
Mario F Rubin1, Stephen M Brunelli, Raymond R Townsend
1Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
Pulse and blood pressure (BP) variability in patients is significant for clinical management. Understanding this variability is crucial for accurate patient assessment in primary care.
Area of Science:
- Cardiology
- Primary Care Medicine
- Clinical Assessment
Background:
- Pulse and blood pressure (BP) are fundamental vital signs routinely monitored in primary care.
- Significant variability exists in both heart rate and BP measurements within individual patients over time and between patients.
- The clinical significance of this variability is often underappreciated.
Purpose of the Study:
- To review the assessment methods for heart rate and blood pressure variability.
- To emphasize the clinical importance of within-patient variability in these vital signs.
- To discuss the differing significance attributed to heart rate and BP measurements.
Main Methods:
- Focused review of existing literature on vital sign variability.
- Analysis of the clinical implications of heart rate and BP fluctuations.
- Discussion of the clinical utility and interpretation of pulse and BP data.
Main Results:
- Variability in pulse and BP is a common and expected finding in clinical practice.
- Understanding patient-specific variability provides critical insights for clinical management.
- Current clinical practice may not fully leverage the information contained in vital sign variability.
Conclusions:
- Variability in pulse and blood pressure is a key indicator that warrants careful clinical consideration.
- Further attention to the assessment and interpretation of vital sign variability is needed in primary care.
- Standardized approaches to evaluating vital sign variability could enhance patient care and clinical decision-making.
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