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A Contrast of Three Inoculation Techniques used to Determine the Race of Unknown Fusarium oxysporum f.sp. niveum Isolates
Published on: October 28, 2021
[Fusarium in dermatology]
1Universitätsklinikum Jena, Klinik für Dermatologie und dermatologische Allergologie, Deutschland. Florian.Seyfarth@med.uni-jena.de
Abstract:
The relevance of infections with moulds in humans is increasing. Relevant genera are Alternaria, Cladosporium, Scopulariopsis, and Fusarium. Fusarium thereby is characterized by typical makroconidia and special makroscopical features. Known as pathogen in plants the fungi can also cause intoxications and - more seldom - infections, mainly in immunosuppressed patients. Problematic are infections of the eye, which were described in users of contact lenses, they are difficult to treat. Manifestations of skin fusariosis are necroses, ulcerations, papulo-pustular skin lesions as well as abscesses and paronychia. In immuno-compromised patients, these circumscribed lesions can merge into generalized infections. Thus, systemical fusariosis is one differential diagnosis in neutropenic fever. Thereby, systemic fusariosis is often associated with generalized papular and nodular skin lesions, which tend to ulcerate. In some cases, these lesions may be surrounded by a targetoid erythema. Altogether, the prognosis of systemic fusariosis is not favourable. Thus, early diagnosis of the disease is crucial and requires especially the dermatologist as medical consultant.
Insights
Fungal infections, particularly Fusarium, are a growing concern. Early diagnosis by dermatologists is crucial for treating skin and systemic fusariosis, especially in immunocompromised individuals.
Area of Science:
- Medical Mycology
- Dermatology
- Infectious Diseases
Context:
- Increasing prevalence of human fungal infections.
- Emergence of Fusarium as a significant pathogen.
- Challenges in treating Fusarium infections, especially ocular and in immunocompromised patients.
Purpose:
- To highlight the clinical significance of Fusarium infections.
- To describe the diverse manifestations of fusariosis, including skin and systemic forms.
- To emphasize the importance of early diagnosis and dermatological consultation.
Summary:
- Fusarium, a fungus known for plant pathology, causes human infections, including difficult-to-treat eye infections and skin conditions like necroses and ulcerations.
- Systemic fusariosis presents with skin lesions and can be a differential diagnosis in neutropenic fever, often with a poor prognosis.
- Prompt identification by dermatologists is essential for effective management of Fusarium infections.
Impact:
- Enhances understanding of Fusarium as a human pathogen.
- Underscores the need for increased clinical vigilance for fusariosis.
- Promotes timely dermatological intervention for improved patient outcomes.
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