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Preplaced Aggregate Concrete01:29

Preplaced Aggregate Concrete

Preplaced aggregate concrete is ideal for construction environments that are not easily accessible. The process begins by properly wetting the gap-graded coarse aggregates to remove the dirt, then placing it in the form and compacting it. Voids are filled with a mortar mix pumped under pressure through slotted pipes. This mortar typically consists of Portland cement, pozzolan, fine aggregates, water, and a fluidizing aid. The pozzolan helps reduce bleeding and segregation while improving the...
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Novel compaction techniques with pellet-containing granules.

Xin Pan1, Meiwan Chen, Ke Han

  • 1College of Pharmacy, Sun Yat-sen University, Guangzhou, PR China; Research and Development Center of Pharmaceutical Engineering, Sun Yat-sen University, Guangzhou, PR China.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|May 4, 2010
PubMed
Summary
This summary is machine-generated.

A novel granulation method improves tablet uniformity by creating pellet-containing granules. This technique enhances the mixture of coated pellets and cushioning granules, ensuring consistent weight and drug content without affecting drug release.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Formulation Science

Background:

  • Achieving uniform drug content in tablets containing coated pellets is challenging due to segregation issues.
  • Traditional direct compression methods can lead to poor content uniformity when mixing coated pellets with excipients.

Purpose of the Study:

  • To introduce and evaluate a new method for preparing segregation-free combinations of coated pellets and excipients.
  • To improve the uniformity of tablets containing coated pellets through a granulation approach.

Main Methods:

  • Acrylic polymeric-coated pellets were granulated using a centrifugal method with various excipients.
  • Pellet-containing granules were then compacted into tablets with cushioning granules.
  • Control tablets were prepared by direct compression of coated pellets and cushioning granules.

Main Results:

  • Granulation roughened the surface of coated pellets, increasing their angle of repose for better compatibility with cushioning granules.
  • Tablets made with pellet-containing granules exhibited significantly lower weight and drug content variability (RSD) compared to direct compression.
  • Drug release profiles remained consistent (f(2) > 50) with the original coated pellets when using MCC, PVPP, or lactose as granulating agents.

Conclusions:

  • The granulation process effectively enhances the uniformity of mixtures containing coated pellets and cushioning granules.
  • Tablets prepared using the pellet-containing granule method demonstrate superior content and weight uniformity.
  • The developed granulation and compression processes maintain the integrity of coated pellets and their enteric dissolution properties.