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Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Stroke: Introduction and Types

Stroke: Introduction and Types

A stroke is an acute neurological event caused by the sudden disruption of cerebral blood flow, leading to rapid loss of neuronal function. Neurons depend on continuous oxygen and glucose supply, so even brief interruptions can cause irreversible injury within minutes. Strokes are classified into ischemic and hemorrhagic types.Ischemic StrokeIschemic strokes are most common and occur due to arterial occlusion, depriving brain tissue of oxygen and nutrients. This leads to energy failure, ionic...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 13, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Stroke in patients with dengue.

Stephen Mathew¹, Jeyaraj Durai Pandian¹

¹Stroke Unit, Christian Medical College, Ludhiana, Punjab, India.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association

|May 4, 2010

Summary

Dengue virus infection can cause stroke, even though it is uncommon. This study highlights three cases of stroke in patients with dengue, emphasizing the need for consideration in epidemic regions.

Area of Science:

Neurology
Infectious Diseases
Public Health

Background:

Central nervous system infections are a significant cause of stroke, particularly in developing nations.
Stroke following dengue infection is considered rare, making its occurrence noteworthy.

Observation:

This case series details three patients diagnosed with dengue during a 2008 epidemic who subsequently experienced stroke.
Clinical presentations included hemorrhagic foci, cerebellar hemorrhages with hydrocephalus, and parietal lobe infarcts, confirmed by MRI.
All patients exhibited thrombocytopenia (low platelet count), with one fatality.

Findings:

Dengue infection can manifest with severe neurological complications, including ischemic and hemorrhagic stroke.
The observed cases underscore the potential for dengue to trigger cerebrovascular events.

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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

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Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

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Implications:

Dengue should be considered a potential cause of stroke in epidemic areas, especially when patients present with fever and neurological deficits.
Increased awareness and diagnostic vigilance for dengue-associated stroke are crucial for timely management and improved patient outcomes.