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Neurofibroma in the left mandible: a case report
Qian Tao1, Yi Wang, Chaoqun Zheng
1Department of Oral and Maxillofacial Surgery, Guanghua School and Hospital of Stomatology, Sun Yat-Sen University, Guangdong, China. taoqian@mail.sysu.edu.cn
The Kaohsiung Journal of Medical Sciences
|May 4, 2010
Summary
A rare isolated neurofibroma occurred in the mandible without a family history of neurofibromatosis type 1. This benign jaw tumor highlights that neurofibromas can present sporadically, even without systemic signs.
Area of Science:
- Oral pathology
- Neurosurgery
- Oncology
Background:
- Neurofibromas are typically associated with neurofibromatosis type 1 (NF1).
- Isolated neurofibromas, particularly in the mandible, are uncommon.
- Understanding the presentation of sporadic tumors is crucial for diagnosis.
Observation:
- A case of a solitary neurofibroma in the left mandible is presented.
- The patient had no family history or clinical stigmata of NF1.
- Histopathological and immunohistochemical analyses were performed.
Findings:
- Immunohistochemistry confirmed S-100 protein positivity, characteristic of neural crest origin.
- Vimentin (Vim), HMB45, and HHF35 markers were negative, ruling out other tumor types.
- Microscopic examination revealed fusiform cells in a plexiform pattern, consistent with neurofibroma.
Implications:
- This case suggests that isolated mandibular neurofibromas can occur independently of NF1.
- It emphasizes the importance of considering sporadic benign tumors in the differential diagnosis of jaw lesions.
- Further research may elucidate the specific genetic or molecular pathways involved in isolated neurofibroma development.
