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The Stroke Preclinical Assessment Network Multi-Laboratory Model of Thromboembolic Stroke with Thrombolysis: TE-MCAo
Published on: December 19, 2025
Thrombolysis for acute arterial occlusion
1Service of Interventional Radiology, Ospedale Regionale di Lugano, sede Civico, Lugano, Switzerland. jos.vandenberg@eoc.ch
Journal of Vascular Surgery
|May 4, 2010
Summary
Catheter-directed thrombolysis is a valuable treatment for acute leg ischemia, offering a complementary approach to revascularization with a low complication rate. This therapy helps prevent amputation and death in critical limb ischemia patients.
Area of Science:
- Vascular Surgery
- Interventional Radiology
Background:
- Acute leg ischemia presents significant risks, including amputation and mortality.
- Catheter-based thrombolytic therapy is a key treatment modality for acute leg ischemia.
Purpose of the Study:
- To provide an overview of current opinions on catheter-based thrombolytic therapy for acute leg ischemia.
Main Methods:
- Systematic literature review from 1980 to 2009.
- Analysis of randomized trials, case series, and review articles.
Main Results:
- Identified three randomized trials and 14 review articles.
- Detailed pharmacologic aspects, outcomes, indications, contraindications, and complications of thrombolytic therapy.
Conclusions:
- Catheter-directed thrombolysis serves as a complementary, not competing, technology to surgical or percutaneous revascularization.
- This approach demonstrates an acceptably low complication rate.
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