Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amyloidosis.

A S Cohen1, L A Jones

  • 1Boston City Hospital, Boston University School of Medicine, Massachusetts.

Current Opinion in Rheumatology
|February 1, 1991
PubMed
Summary
This summary is machine-generated.

Recent findings reveal new proteins causing amyloidosis, a disease marked by abnormal protein deposits. This necessitates a revised classification and highlights diverse clinical impacts and potential treatments for amyloid diseases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Solar irradiance and ENSO affect food security in Lake Tanganyika, a major African inland fishery.

Science advances·2020
Same author

Corrigendum to 'Plasma concentrations of long chain N-3 fatty acids in early and mid-pregnancy and risk of early preterm birth'.

EBioMedicine·2020
Same author

Plasma Concentrations of Long Chain N-3 Fatty Acids in Early and Mid-Pregnancy and Risk of Early Preterm Birth.

EBioMedicine·2018
Same author

Oil extraction imperils Africa's Great Lakes.

Science (New York, N.Y.)·2016
Same author

Elevated fetal steroidogenic activity in autism.

Molecular psychiatry·2014
Same author

Paroxysmal hemicrania responding to topiramate.

BMJ case reports·2011
Same journal

New approaches to the management of cutaneous lupus.

Current opinion in rheumatology·2026
Same journal

"Updates in chronic nonbacterial osteomyelitis: emerging insights across the age spectrum".

Current opinion in rheumatology·2026
Same journal

Difficult-to-treat, complex-to-manage, treatment-refractory spondyloarthritis: semantics or substance?

Current opinion in rheumatology·2026
Same journal

Update on IgA nephropathy: implications for treatment in IgA vasculitis: a guide for rheumatologists.

Current opinion in rheumatology·2026
Same journal

Polyarticular juvenile idiopathic arthritis: insights from genetic studies on disease risk and pathogenesis.

Current opinion in rheumatology·2026
Same journal

Immune dysregulation in children with Down syndrome: clinical implications and emerging therapies.

Current opinion in rheumatology·2026
See all related articles

Area of Science:

  • Biochemistry
  • Pathology
  • Molecular Biology

Background:

  • Amyloidosis is characterized by fibrillar protein deposition, identified by Congo red staining and green birefringence.
  • Recent advancements have expanded the understanding of proteins involved in amyloid formation.

Purpose of the Study:

  • To review newly identified amyloid-related proteins.
  • To discuss the need for a revised nomenclature and classification of amyloidosis.
  • To outline the clinical manifestations, treatment, and prognosis of amyloidosis.

Main Methods:

  • Literature review of recent findings on amyloidosis.
  • Summarization of an international symposium on amyloidosis nomenclature.
  • Description of clinical manifestations by organ system.

Related Experiment Videos

Main Results:

  • Several new proteins implicated in amyloid deposition have been identified, including transthyretin, apolipoprotein A-1, cystatin C, gelsolin, amyloid beta protein, beta 2-microglobulin, scrapie protein, and islet amyloid polypeptide.
  • A revised nomenclature and classification scheme for amyloidosis is proposed.
  • Varied clinical presentations and organ involvement in amyloidosis are detailed.

Conclusions:

  • The growing list of amyloid-related proteins necessitates updated classification systems.
  • Understanding the diverse clinical spectrum of amyloidosis is crucial for diagnosis and management.
  • New therapeutic interventions for amyloidosis are being explored.