Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microbiota Modulation by Antibiotics01:21

Microbiota Modulation by Antibiotics

Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...
Antibiotic Selection00:57

Antibiotic Selection

Overview
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration01:23

Pharmacokinetic–Pharmacodynamic Relationship: Influence of Elimination Half-Life on Effect Duration

Drug elimination from the body primarily occurs through metabolic and excretion pathways. Hepatic metabolism transforms lipophilic drugs into hydrophilic forms for excretion, typically via enzymatic processes classified as phase I (modification) and phase II (conjugation). Renal excretion eliminates drugs and metabolites through filtration and secretion in the kidneys. Impairment in liver or kidney function can hinder these processes, delaying drug clearance and extending the drug’s half-life.
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Overwhelmed, uncertain, or calm: Lessons from patients with acute infections in the emergency department. A qualitative interview study.

Patient education and counseling·2026
Same author

Variation in antibiotic use across intensive care units in the Netherlands.

Journal of critical care·2026
Same author

Antibiotic allergy delabeling requires more than guidelines: the role of patient perspective.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2026
Same author

Stakeholder perspectives on the offer and acceptance of self-administration of outpatient parenteral antimicrobial therapy: a qualitative study.

The Journal of antimicrobial chemotherapy·2026
Same author

Prioritized barriers to implementation of personalized immunotherapy for sepsis patients.

Implementation science communications·2026
Same author

Factors promoting or hindering self-administered outpatient parenteral antimicrobial therapy: a systematic literature review.

The Journal of antimicrobial chemotherapy·2026

Related Experiment Video

Updated: Jun 13, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

Antibiotic use: how to improve it?

Marlies E J L Hulscher1, Jos W M van der Meer, Richard P T M Grol

  • 1Scientific Institute for Quality of Healthcare, IQ healthcare, Radboud University Nijmegen Medical Centre, The Netherlands. M.Hulscher@IQ.UMCN.nl

International Journal of Medical Microbiology : IJMM
|May 4, 2010
PubMed
Summary
This summary is machine-generated.

Appropriate antibiotic use is crucial to combat antimicrobial resistance. Effective strategies require understanding complex factors influencing prescribing behavior across patient, professional, organizational, and societal levels.

More Related Videos

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Related Experiment Videos

Last Updated: Jun 13, 2026

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations
11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Area of Science:

  • Medical Microbiology
  • Public Health
  • Health Policy

Background:

  • Antibiotics are vital for treating infections, but rising antimicrobial resistance poses a significant threat.
  • Appropriate antibiotic use is essential to preserve treatment efficacy and combat resistance.
  • Understanding the multifaceted determinants of antibiotic prescribing is key to developing effective interventions.

Purpose of the Study:

  • To analyze the factors influencing appropriate and inappropriate antibiotic use.
  • To identify determinants across patient, professional, organizational, and socio-cultural levels.
  • To propose measures for rationalizing antibiotic prescribing.

Main Methods:

  • Analysis of factors influencing antibiotic prescribing behavior.
  • Identification of determinants at four distinct levels: patient, professional, organizational, and socio-cultural.
  • Development of potential intervention strategies tailored to identified determinants.

Main Results:

  • Inappropriate antibiotic use stems from complex, multi-level factors.
  • Determinants include patient knowledge, healthcare professional behavior, care organization, and the socio-cultural environment.
  • Effective interventions must address all identified levels.

Conclusions:

  • A comprehensive national program for appropriate antibiotic use is recommended.
  • Such a program should integrate patient, professional, and organizational activities.
  • International cooperation is vital for guidelines, monitoring, and implementation.