Dynamic susceptibility contrast-enhanced MRI evaluation of cerebral intraventricular tumors: preliminary results
1Neuroradiology Department, hôpital Central, CHU de Nancy, 54000 Nancy, France. antoine.holveck@hotmail.fr
Introduction:
The aims of the present study were to determine the perfusion characteristics of several types of intraventricular tumors and to evaluate the usefulness of dynamic contrast-enhanced MRI in making the differential diagnosis.
Methods:
A total of 28 patients with intraventricular tumors (five meningiomas, five papillomas, three ependymomas, four subependymomas, seven central neurocytomas, two subependymal giant cell astrocytomas and two metastases) underwent conventional and dynamic susceptibility contrast-enhanced MRI. Cerebral blood volume (CBV) maps were obtained and the relative CBV (rCBV) calculated for each tumor. Mean rCBV(max) values were compared across the different types of tumors (ANOVA, P=0.05).
Results:
Intraventricular tumors presented with three different patterns of vascularization: highly vascularized tumors (mean rCBV(max)>3), including papillomas, meningiomas and renal carcinoma metastases; poorly vascularized tumors (mean rCBV(max)<2), including ependymomas and subependymomas; and intermediately vascularized tumors (mean rCBV(max)>2 but<3), including central neurocytomas and lung metastases. There was a significant difference between the highly vascularized (papillomas, meningiomas) and poorly vascularized (subependymomas) tumors. In cases of suspected meningioma, papilloma or neurocytoma, low rCBV values (<3) point to a diagnosis of neurocytoma rather than either of the other tumor types.
Conclusion:
Susceptibility contrast-enhanced MRI can provide additional information on the vascularization of intraventricular cerebral tumors and may help in making the differential diagnosis.
Insights
Dynamic contrast-enhanced MRI reveals distinct vascularization patterns in intraventricular tumors. Relative cerebral blood volume (rCBV) measurements aid in differentiating tumor types, improving diagnostic accuracy.
Area of Science:
- Neuroradiology
- Oncology
- Medical Imaging
Background:
- Intraventricular tumors exhibit diverse perfusion characteristics.
- Accurate differential diagnosis is crucial for effective treatment planning.
Purpose of the Study:
- To characterize perfusion in various intraventricular tumors using dynamic contrast-enhanced MRI.
- To assess the utility of this technique in differential diagnosis.
Main Methods:
- 28 patients with intraventricular tumors underwent conventional and dynamic susceptibility contrast-enhanced MRI.
- Cerebral blood volume (CBV) maps were generated, and relative CBV (rCBV) was calculated.
- Statistical analysis (ANOVA) compared mean rCBV(max) values across tumor types.
Main Results:
- Tumors were classified into highly (rCBV(max)>3), poorly (rCBV(max)<2), and intermediately (2
- Papillomas, meningiomas, and metastases were highly vascularized; ependymomas and subependymomas were poorly vascularized.
- Central neurocytomas and some metastases showed intermediate vascularization.
Conclusions:
- Dynamic contrast-enhanced MRI provides valuable insights into intraventricular tumor vascularity.
- rCBV measurements can assist in differentiating between specific intraventricular tumor types.
