Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives
Omaima M Abdelhafez1, Kamelia M Amin, Rasha Z Batran
1Department of Chemistry of Natural Products, National Research Center, Dokki, Cairo, Egypt. ommryan@yahoo.com
Abstract:
The action of the coumarin-type drugs and related compounds is reviewed to their VKOR antagonistic effects. In our study, twenty 3-pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement of PIVKA-II levels) anticoagulant study with respect to warfarin showed that the synthesized compounds have different anticoagulant activities, the most prospective compounds were the 3-pyrazolyl-4-hydroxycoumarin derivatives.
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