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Post-challenge hyperglycaemia is strongly associated with future macrovascular events and total mortality in

Harald Sourij1, Christoph H Saely, Fabian Schmid

  • 1Metabolism and Vascular Biology Research Group, Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria.

European Heart Journal
|May 4, 2010
PubMed

Insights

Post-challenge hyperglycaemia in coronary patients significantly increases the risk of future macrovascular events. An oral glucose tolerance test (oGTT) identifies these high-risk individuals with an unfavorable prognosis.

Area of Science:

  • Cardiology
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Post-challenge hyperglycaemia is prevalent in patients with coronary artery disease.
  • The association between post-challenge hyperglycaemia and macrovascular events in this population remains unclear.

Purpose of the Study:

  • To investigate the risk of future macrovascular events in coronary patients with post-challenge hyperglycaemia.

Main Methods:

  • 1040 patients undergoing coronary angiography were enrolled.
  • Oral glucose tolerance tests (oGTT) were performed in patients without pre-existing diabetes.
  • Macrovascular events and mortality were prospectively recorded over a 3.8-year follow-up.

Main Results:

  • Patients with post-challenge hyperglycaemia (280) and conventional diabetes (366) had significantly higher macrovascular event rates than those with normal glucose tolerance (394).
  • Adjusted hazard ratios for macrovascular events were 1.46 for post-challenge hyperglycaemia and 1.73 for conventional diabetes.
  • Post-challenge hyperglycaemia indicates a particularly unfavorable prognosis in stable coronary artery disease patients.

Conclusions:

  • Post-challenge hyperglycaemia is linked to increased future macrovascular events in patients evaluated for coronary artery disease.
  • oGTTs identify high-risk individuals with poor prognosis in this population.
Abstract

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