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Updated: Jun 13, 2026
07:29
Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
Evidence-based clinical recommendations regarding screening for oral squamous cell carcinomas.
Michael P Rethman1, William Carpenter, Ezra E W Cohen
1College of Dentistry, The Ohio State University, Columbus, OH, USA.
Summary
Routine oral cancer screening may detect early-stage cancers, but evidence is insufficient to confirm if it reduces mortality in asymptomatic individuals. Dentists should remain vigilant for suspicious lesions, especially in high-risk patients.
Area of Science:
- Oral oncology
- Dental screening protocols
- Public health dentistry
Background:
- Evidence-based clinical recommendations for oral cancer screening.
- Evaluation of potential benefits and risks of screening for oral squamous cell carcinomas.
- Assessment of adjunctive screening aids for detecting oral lesions.
Purpose of the Study:
- To develop clinical recommendations for oral cancer screening.
- To evaluate the efficacy of visual and tactile examinations and adjunctive aids.
- To inform dental professionals on best practices for early detection.
Main Methods:
- Systematic search of MEDLINE database.
- Inclusion of 332 systematic reviews and 1,499 clinical studies.
- Selection of 5 systematic reviews and 4 clinical studies for analysis.
Main Results:
- Screening can detect oral cancers at early developmental stages.
- Insufficient evidence exists to determine if screening impacts disease-specific mortality in asymptomatic patients.
- Visual and tactile examinations are key components of screening.
Conclusions:
- Clinicians should remain alert for potentially malignant lesions or early cancers during routine examinations.
- Increased vigilance is advised for patients with risk factors like tobacco and alcohol use.
- Further research on oral cancer screening methods and adjuncts is necessary.
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