Related Experiment Video

Updated: Jun 13, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Fetuin-A is associated with calcified coronary artery disease

Katsuhito Mori1, Yuji Ikari, Shuichi Jono

  • 1Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan. ktmori@med.osaka-cu.ac.jp

Coronary Artery Disease
|May 4, 2010
PubMed

Insights

Serum fetuin-A levels were lower in patients with calcified coronary artery disease. This suggests fetuin-A may play a protective role against atherosclerosis progression in individuals without diabetes or kidney dysfunction.

Area of Science:

  • Cardiovascular Research
  • Biochemistry
  • Atherosclerosis Studies

Background:

  • Fetuin-A is a glycoprotein implicated in atherosclerosis.
  • Its role in cardiovascular disease is debated, especially in patients with diabetes and uremia.
  • Fetuin-A may inhibit calcification, potentially protecting against advanced atherosclerosis.

Purpose of the Study:

  • To investigate the association between serum fetuin-A levels and calcified coronary artery disease.
  • To clarify fetuin-A's role in cardiovascular disease in individuals without diabetes and renal dysfunction.

Main Methods:

  • Serum fetuin-A levels were measured in 92 participants undergoing coronary angiography.
  • Coronary artery stenosis and calcification were assessed.
  • Multivariate logistic regression analyzed the correlation between fetuin-A and calcification.

Main Results:

  • Fetuin-A levels were significantly lower in patients with three-vessel disease compared to those without stenosis.
  • Patients with coronary artery calcification had lower fetuin-A levels than those without.
  • Fetuin-A levels inversely correlated with the presence of coronary artery calcification (OR: 0.54; 95% CI: 0.31-0.92).

Conclusions:

  • Serum fetuin-A levels are inversely correlated with advanced calcified coronary artery disease.
  • Fetuin-A may be a protective factor against calcified coronary atherosclerosis in non-diabetic, non-uremic individuals.
Abstract

More Related Videos

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images08:02

Novel Quantification Protocol for Cardiovascular Calcification Progression Using Longitudinal MicroPET/MicroCT Images

Published on: November 15, 2024

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro11:30

A Semi-Automated and Reproducible Biological-Based Method to Quantify Calcium Deposition In Vitro

Published on: June 2, 2022

Related Concept Videos

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...