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Published on: November 9, 2018
Assessment of serum L-fucose in brain tumor cases
S Manjula1, Flama Monteiro, Annaya Rao Aroor
1Department of Biochemistry, Yenepoya Medical College, Mangalore, India.
Background:
Glycosylation of altered tumor cell in relation to cellular heterogeneity in human intracranial tumors remains relatively unexposed. Serum protein-bound carbohydrate, L-Fucose is reported to be overexpressed during tumor progression by many investigators. Therefore, there is a need to determine the diagnostic, prognostic, functional significance of glycoprotein elevations in various cases of tumors.
Objective:
The objective of the present study was to evaluate the clinical utility of serum L-fucose in patients with brain tumor.
Materials And Methods:
Serum glyco-conjugate levels were estimated in 99 patients with brain tumors. Estimation of L-fucose was carried out colorimetrically by the method of Winzler using cysteine hydrochloride.
Results:
There was a significant increase in L-fucose level in most of the patients. In the posttreatment cases, the L-fucose levels were apparently low compared to preoperative values.
Conclusion:
Our results showed that the rise in serum L-fucose may be used as a general marker for brain tumors in addition to other markers.
