Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Agreeing Language in Veterinary Endocrinology (ALIVE): Hypothyroidism, Hyperthyroidism, (Euglycaemic) Diabetic Ketosis/Ketoacidosis, and Diabetic Remission-A Modified Delphi-Method-Based System to Create Consensus Definitions.

Veterinary sciences·2026
Same author

Spontaneous adult-onset primary hypothyroidism in 17 cats.

Journal of feline medicine and surgery·2025
Same author

Iatrogenic Primary Hypothyroidism Associated With Sulfamethoxazole-Trimethoprim Treatment of Nocardiosis in a Cat.

Journal of veterinary internal medicine·2025
Same author

Hyperthyroid cats that develop azotemia following successful radioiodine treatment have shorter survival times compared to cats that remain nonazotemic.

Journal of the American Veterinary Medical Association·2024
Same author

Serum metabolome analysis in hyperthyroid cats before and after radioactive iodine therapy.

PloS one·2024
Same author

Blood pressure in hyperthyroid cats before and after radioiodine treatment.

Journal of veterinary internal medicine·2024
Same journal

Ethylene glycol intoxication: Use of the lactate gap for diagnosis and to determine length of intermittent hemodialysis treatment.

The Canadian veterinary journal = La revue veterinaire canadienne·2026
Same journal

Medical management of multifocal immune-mediated punctate keratitis in 3 dogs: A case series.

The Canadian veterinary journal = La revue veterinaire canadienne·2026
Same journal

Apramycin resistance in bacteria isolated from animals: A systematic review and meta-analysis.

The Canadian veterinary journal = La revue veterinaire canadienne·2026
Same journal

Diagnostic Ophthalmology.

The Canadian veterinary journal = La revue veterinaire canadienne·2026
Same journal

Is there a difference between locum and employed veterinarians?

The Canadian veterinary journal = La revue veterinaire canadienne·2026
Same journal

Veterinary medicine and One Health in the age of AI.

The Canadian veterinary journal = La revue veterinaire canadienne·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

Canine hypoadrenocorticism: part II.

Susan C Klein1, Mark E Peterson

  • 1scklein@hotmail.com

The Canadian Veterinary Journal = La Revue Veterinaire Canadienne
|May 4, 2010
PubMed
Summary
This summary is machine-generated.

Hypoadrenocorticism in dogs requires prompt diagnosis and treatment for acute crises and chronic conditions. Early intervention leads to an excellent long-term prognosis for affected canine patients.

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Related Experiment Videos

Last Updated: Jun 13, 2026

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
08:02

Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids

Published on: April 25, 2016

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions
04:33

Primary Culture of Rat Adrenocortical Cells and Assays of Steroidogenic Functions

Published on: March 12, 2019

Area of Science:

  • Veterinary Medicine
  • Canine Endocrinology

Background:

  • Hypoadrenocorticism, or Addison's disease, affects dogs with gastrointestinal signs.
  • Part I of this series detailed the etiology, pathophysiology, and diagnostic abnormalities.
  • This article focuses on diagnosis and treatment strategies.

Purpose of the Study:

  • To outline definitive diagnostic methods for hypoadrenocorticism in dogs.
  • To describe treatment protocols for both acute and chronic Addisonian patients.
  • To emphasize the importance of owner education for long-term management.

Main Methods:

  • Review of diagnostic criteria for hypoadrenocorticism.
  • Discussion of treatment options for acute Addisonian crisis.
  • Outline of long-term management strategies for chronic hypoadrenocorticism.

Main Results:

  • Expedient treatment is crucial for patients in acute Addisonian crisis.
  • Definitive diagnosis and management are key for both acute and chronic cases.
  • Well-educated owners contribute to an excellent long-term prognosis.

Conclusions:

  • Prompt diagnosis and treatment of canine hypoadrenocorticism are essential.
  • Effective management strategies exist for both acute and chronic presentations.
  • Owner vigilance and education are vital for successful long-term outcomes in dogs with Addison's disease.