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Related Experiment Video

Updated: Jun 13, 2026

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Evaluation of Host-Pathogen Responses and Vaccine Efficacy in Mice

Published on: February 22, 2019

[Pertussis keeps on killing].

Joana Freitas¹, Susana Gama de Sousa, Cristina Miguel

¹Serviço de Pediatria, CHMA, EPE - Unidade de Famalicão.

Revista Portuguesa De Pneumologia

|May 4, 2010

Summary

Pertussis (whooping cough) is a dangerous bacterial infection. Early recognition and new vaccination strategies are crucial to protect vulnerable infants from this potentially fatal disease, as pertussis is not expected to be eradicated soon.

Area of Science:

Pediatrics
Infectious Diseases
Public Health

Background:

Pertussis, caused by Bordetella pertussis, is a highly infectious global respiratory illness.
Recent years show an increase in pertussis cases, with adolescents and adults emerging as significant infection sources for infants.

Observation:

A 36-day-old infant presented with respiratory distress and cyanosing cough, suspected pertussis complicated by pneumonia.
Initial treatment with broad-spectrum antibiotics was initiated, but the infant's condition worsened.

Findings:

The infant developed hyperleukocytosis and thrombocytosis, was transferred to the ICU, and died within 20 hours due to pulmonary hypertension and hemorrhage.
Pertussis infection was confirmed via PCR.

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Implications:

The case highlights the critical need for recognizing pertussis, even in atypical presentations, for timely diagnosis and treatment.
Emphasizes the importance of reporting, disease prevention, and developing new vaccination strategies to protect vulnerable populations, particularly unvaccinated infants.