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H1/H1 genotype influences symptom severity in corticobasal syndrome
Irene Litvan1, Amanda Chism, Juan Litvan
1Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky 40202, USA. i.litvan@louisville.edu
Abstract:
We evaluated 38 consecutive patients with corticobasal syndrome to determine if inheritance of the H1/H1 genotype influences age at onset and disease severity and if Apolipoprotein E e4 increases the risk of cognitive disturbances. Inheritance of the H1/H1 genotype was associated with severity of motor function, but did not affect age at onset or cognition. There was a trend toward shorter survival in the H1/H1 group, but this study was underpowered to test influence on survival, even though it served to estimate the sample size for future studies. ApoE inheritance did not influence cognition.
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