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Related Experiment Video

Updated: Jun 13, 2026

Contrast Enhanced Ultrasound Imaging for Assessment of Spinal Cord Blood Flow in Experimental Spinal Cord Injury

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Quercetin administration after spinal cord trauma changes S-100 levels.

E Schültke¹, R W Griebel, B H J Juurlink

¹Department of Anatomy & Cell Biology, Division of Neurosurgery, University of Saskatchewan, Saskatoon, SK, Canada.

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques

|May 5, 2010

Summary

Quercetin administration modifies S-100beta levels after spinal cord trauma in rats. This suggests quercetin may reduce central nervous system (CNS) injury severity.

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Area of Science:

Neuroscience
Biochemistry
Pharmacology

Background:

S-100beta protein levels in serum correlate with central nervous system (CNS) trauma severity.
S-100beta in CNS tissue plays a role in neuroprotection and neuroregeneration.
Previous studies demonstrated quercetin improves motor function in spinal cord injury models.

Purpose of the Study:

To investigate the effect of quercetin administration on S-100beta levels in serum and CNS tissue following experimental spinal cord trauma.
To assess the potential neuroprotective role of quercetin in spinal cord injury.

Main Methods:

Adult male Wistar rats underwent mid-thoracic spinal cord compression injury.
Animals received quercetin (25 micromol/kg) or saline (control).
Serum and tissue S-100beta levels were measured at 6, 12, and 24 hours post-injury using a luminometric assay.

Main Results:

Quercetin treatment ameliorated the increase in serum S-100beta levels post-trauma compared to controls, becoming significant at 24 hours.
Tissue S-100beta levels decreased in saline controls but were initially decreased then increased at later time points in quercetin-treated rats.
Tissue S-100beta levels were significantly higher in quercetin-treated animals than saline controls at all measured time points.

Conclusions:

Quercetin administration alters S-100beta kinetics in experimental spinal cord trauma.
The observed changes in S-100beta levels suggest quercetin administration post-trauma may mitigate CNS injury extent.