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Related Concept Videos

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis01:30

Extracorporeal Removal of Drugs: Peritoneal Dialysis and Hemodialysis

Patients with end-stage renal disease (ESRD) or those experiencing drug overdose often require extracorporeal methods to eliminate accumulated drugs and metabolites. Hemoperfusion, hemofiltration, and dialysis are the primary techniques to rapidly remove harmful substances without disrupting the patient's fluid and electrolyte balance. For those with compromised renal function, dosage adjustments of concurrent medications may be necessary during extracorporeal drug removal.Dialysis is a process...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration01:25

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...

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Related Experiment Video

Updated: Jun 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Plasma exchange in elderly patients.

Nikolina Basic-Jukic1, Bruna Brunetta, Petar Kes

  • 1Department of Dialysis, University Hospital Centre Zagreb, Zagreb, Croatia. nina_basic@net.hr

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|May 5, 2010
PubMed
Summary
This summary is machine-generated.

Plasma exchange (PE) is a safe and effective treatment for elderly patients, showing significant improvement in 94% of cases. While complications were higher than in younger patients, PE offers considerable benefits for older individuals with specific medical conditions.

Related Experiment Videos

Last Updated: Jun 13, 2026

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

Area of Science:

  • Nephrology
  • Neurology
  • Geriatrics

Background:

  • Plasma exchange (PE) is an extracorporeal therapy for removing large molecules from plasma.
  • Limited data exists on PE utilization and outcomes in elderly populations.
  • This study investigates PE in patients aged 65 and older.

Purpose of the Study:

  • To analyze the indications and complications of plasma exchange in elderly patients.
  • To evaluate the efficacy and safety of PE in this demographic.

Main Methods:

  • Retrospective analysis of a database from the University Hospital Center Zagreb (1982-2007).
  • Inclusion criteria: patients aged 65+ undergoing PE.
  • Data collected on patient demographics, procedures, indications, replacement fluids, access, and complications.

Main Results:

  • 50 elderly patients underwent 323 PE procedures; 94% showed improvement.
  • Neurological conditions (myasthenia gravis, Guillain-Barré syndrome) were the primary indications (76%).
  • Complication rate was 11.5% in the elderly group, higher than in younger patients, with clotting and access issues being most common.

Conclusions:

  • Plasma exchange is infrequently used in the elderly but is safe and effective when performed by experienced teams.
  • PE can significantly improve outcomes for elderly patients with appropriate indications.
  • Careful monitoring is essential due to a higher complication rate in this age group.