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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Epigenetic Regulation01:37

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
Epigenetic Regulation01:46

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Regulation of Expression at Multiple Steps01:23

Regulation of Expression at Multiple Steps

The gene expression in cells is regulated at different stages: (i) transcription, (ii) RNA processing, (iii) RNA localization, and (iv) translation. Transcriptional regulation is mediated by regulatory proteins such as transcription factors, activators, or repressors—these control gene expression by initiating or inhibiting the transcription of genes. Once a precursor or pre-mRNA is produced, it undergoes post-transcriptional modification, including 5' capping, splicing, and the addition of a...

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Cell Based Assays of SINEUP Non-coding RNAs That Can Specifically Enhance mRNA Translation
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Published on: February 1, 2019

Natural antisense transcripts regulate gene expression in an epigenetic manner.

Wen-Yu Su1, Hua Xiong, Jing-Yuan Fang

  • 1Department of Gastroenterology, Shanghai Jiao-Tong University School of Medicine Renji Hospital, Shanghai Institution of Digestive Disease, Shanghai 200001, China.

Biochemical and Biophysical Research Communications
|May 5, 2010
PubMed
Summary
This summary is machine-generated.

Natural antisense transcripts (NATs) are crucial regulatory RNAs involved in epigenetic processes like DNA methylation and histone modification. These non-coding RNAs offer potential therapeutic targets for diseases such as cancer.

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Last Updated: Jun 13, 2026

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
07:23

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Published on: June 15, 2016

Area of Science:

  • Epigenetics and Molecular Biology
  • RNA Biology

Background:

  • Epigenetic regulation involves DNA methylation, histone modifications, and RNA-mediated gene control.
  • Natural antisense transcripts (NATs) are ubiquitous regulatory RNAs in prokaryotes and eukaryotes.
  • NATs play roles in various physiological and pathological processes.

Purpose of the Study:

  • To explore the role of NATs in epigenetic regulation.
  • To investigate the mechanisms by which NATs interact with other epigenetic factors.
  • To assess the therapeutic potential of NATs in diseases.

Main Methods:

  • Review of existing literature on NATs and epigenetics.
  • Analysis of NATs' involvement in gene expression regulation.
  • Examination of NATs' interactions with DNA methylation and histone modification machinery.

Main Results:

  • NATs are implicated in transcriptional interference, genomic imprinting, X inactivation, and RNA editing.
  • NATs regulate gene expression via direct (sense transcripts) and indirect interactions (epigenetic modifiers).
  • Formation of sense-antisense duplexes by NATs impacts mRNA and protein levels.

Conclusions:

  • NATs are integral components of the epigenetic regulatory network.
  • A potential link exists between NATs, DNA methylation, and histone modifications.
  • NATs represent a promising source for developing novel therapies for cancers and other diseases.