Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
Nuclear Export01:42

Nuclear Export

The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

Nuclear protein sorting regulates nucleus composition and gene expression, crucial for determining the fate of a eukaryotic cell. Hence, the entry and exit of molecules across the nuclear envelope is a tightly controlled process. Nuclear protein sorting can be inhibited by one of the following ways: 1) masking cargo signal sequences, 2) modifying the nuclear receptor's affinity for cargo, 3) controlling the nuclear pore size, 4) retaining the cargo during its transit to the cytosol or the...
Intracellular Hormone Receptors01:08

Intracellular Hormone Receptors

Lipid-soluble hormones diffuse across the plasma and nuclear membrane of target cells to bind to their specific intracellular receptors. These receptors act as transcription factors that regulate gene expression and protein synthesis in the target cell
Nuclear Protein Sorting01:34

Nuclear Protein Sorting

Nuclear protein sorting is the selective trafficking of histones, polymerases, gene regulatory proteins into the nucleus and exporting RNAs and ribosomes to the cytosol. It is a tightly controlled process that regulates gene expression within a cell.
Proteins targeted to the nucleus carry nuclear localization signals or NLS recognized by import receptors in the cytosol. Similarly, proteins with nuclear export signals are recognized by export receptors. Import and export receptors are...
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>C. elegans mlt-11</i> activity is necessary in seam cells for molting and larval development.

microPublication biology·2026
Same author

Impact of Fluorophore and Epitope Position on Destabilized Reporter Performance in <i>C. elegans</i>.

bioRxiv : the preprint server for biology·2026
Same author

Government-Funded Health and Biomedical Research Is Irreplaceable.

NAM perspectives·2026
Same author

Effects of feces storage conditions for host-microbiota screenings in <i>C. elegans</i>.

Frontiers in microbiomes·2026
Same author

Hoi1 targets BLTP2 to ER-PM contact sites to regulate lipid homeostasis.

The Journal of cell biology·2026
Same author

The Caenorhabditis Genetics Center Curated Special Collections: a guide to protein degradation systems.

Genetics·2026

Related Experiment Video

Updated: Jun 13, 2026

Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism
11:20

Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism

Published on: December 11, 2009

Nuclear hormone receptors in nematodes: evolution and function.

Stefan Taubert1, Jordan D Ward, Keith R Yamamoto

  • 1Department of Medical Genetics, University of British Columbia, Centre for Molecular Medicine and Therapeutics, and Child & Family Research Institute, Vancouver, BC, Canada.

Molecular and Cellular Endocrinology
|May 5, 2010
PubMed
Summary
This summary is machine-generated.

Nuclear hormone receptors (NHRs) regulate gene expression. In nematodes like Caenorhabditis elegans, an expanded NHR family may simplify functional analysis of these ancient regulatory proteins.

More Related Videos

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Related Experiment Videos

Last Updated: Jun 13, 2026

Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism
11:20

Osmotic Avoidance in Caenorhabditis elegans: Synaptic Function of Two Genes, Orthologues of Human NRXN1 and NLGN1, as Candidates for Autism

Published on: December 11, 2009

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans
08:12

Identification of EGFR and RAS Inhibitors using Caenorhabditis elegans

Published on: October 5, 2020

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Area of Science:

  • Molecular Biology
  • Genomics
  • Evolutionary Biology

Background:

  • Nuclear hormone receptors (NHRs) are crucial proteins that control gene expression in response to various signals.
  • NHRs possess conserved DNA-binding domains (DBDs) and variable ligand-binding domains (LBDs).
  • Some NHRs are regulated by ligands, while others, known as orphan receptors, lack identified natural ligands.

Purpose of the Study:

  • To explore the function and evolution of NHRs in nematodes, with a specific focus on Caenorhabditis elegans.
  • To investigate the implications of a massively expanded NHR family in C. elegans for functional analysis.
  • To understand how NHRs integrate regulatory inputs including ligands, coregulators, and response elements.

Main Methods:

  • Comparative genomics analysis of NHR families across nematode species.
  • Bioinformatic identification of potential NHR ligands and response elements in C. elegans.
  • Review of existing literature on NHR function and evolution in metazoans and fungi.

Main Results:

  • The C. elegans genome contains a significantly expanded repertoire of NHRs compared to other organisms.
  • This expansion suggests a potential diversification of NHR functions, possibly simplifying the study of individual receptors.
  • NHRs in nematodes interact with diverse gene networks, integrating signals from ligands, coregulators, and genomic response elements.

Conclusions:

  • The expanded NHR family in C. elegans presents a unique model for studying NHR function and evolution.
  • Investigating NHRs in nematodes may offer simplified approaches to identifying cofactors, ligands, and response elements.
  • NHRs play a vital role in nematode biology, with growing relevance to medically important species.