Related Experiment Video

Updated: Jun 13, 2026

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

Does the colon play a role in intestinal adaptation in infants with short bowel syndrome? A multiple variable

Ivan R Diamond1, Marie-Chantal Struijs, Nicole T de Silva

  • 1Group for Improvement of Intestinal Function and Treatment (GIFT), The Hospital for Sick Children, Toronto, Canada M5G 1X8.

Journal of Pediatric Surgery
|May 5, 2010
PubMed

Insights

The colon

Area of Science:

  • Pediatric Surgery
  • Gastroenterology
  • Neonatology

Background:

  • Short bowel syndrome (SBS) is a condition requiring complex management in infants.
  • Intestinal adaptation is crucial for achieving enteral autonomy in SBS patients.
  • The role of residual colonic length in this adaptation process requires further elucidation.

Purpose of the Study:

  • To investigate the impact of residual colonic length on the time to intestinal adaptation in infants with SBS.
  • To identify key predictors of intestinal adaptation in a cohort of surgically treated SBS infants.

Main Methods:

  • A cohort of 106 infants diagnosed with SBS and operated on at 90 days or younger was analyzed.
  • Univariate and stepwise multiple variable Cox proportional hazards models were used to assess time to full enteral feeds.
  • Predictors included multidisciplinary management, surgical procedures, bowel lengths, ileocecal valve status, and septic events.

Main Results:

  • Residual colonic length was not a significant predictor of intestinal adaptation.
  • Key factors influencing adaptation included multidisciplinary management (HR, 1.932), percent small bowel (HR, 1.028), and septic events (HR, 0.695).
  • Preserved ileocecal valve and Serial Transverse Enteroplasty Procedure showed trends towards significance.

Conclusions:

  • The colon's length does not appear to significantly influence intestinal adaptation in infants with SBS.
  • Multidisciplinary intestinal rehabilitation and minimizing septic complications are vital for successful adaptation.
  • Maximizing residual small bowel length remains a critical factor in managing SBS.
Abstract

More Related Videos

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis08:58

Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis

Published on: January 5, 2017

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis07:05

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the small...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Development of Human Microbiota01:30

Development of Human Microbiota

The human microbiota begins developing at birth and undergoes continual change as we age. Infancy marks a critical period of microbial sensitivity, offering a “window of opportunity” during which beneficial microbes help mature the immune system. By age three, children typically develop a more stable and diverse microbial community. Newborns acquire microbes from their immediate environment; vaginal delivery favors maternal vaginal microbes, while cesarean births favor microbes from the skin...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...