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Parathyroid hormone level is associated with mortality and cardiovascular events in patients undergoing coronary

Stefan Pilz1, Andreas Tomaschitz, Christiane Drechsler

  • 1Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria. stefan.pilz@chello.at

European Heart Journal
|May 5, 2010
PubMed

Insights

Elevated parathyroid hormone (PTH) is linked to higher mortality and cardiovascular events in patients undergoing coronary angiography. These findings suggest PTH may be an independent risk factor for poor outcomes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Public Health

Background:

  • Elevated parathyroid hormone (PTH) is linked to cardiovascular disease.
  • The association between PTH levels and cardiovascular outcomes in patients undergoing coronary angiography requires further investigation.

Purpose of the Study:

  • To determine if PTH levels are associated with mortality and fatal cardiovascular events in patients referred for coronary angiography.

Main Methods:

  • Intact PTH levels were measured in 3232 Caucasian patients from the LURIC study.
  • Patients underwent coronary angiography between 1997 and 2000.
  • Follow-up was for a median of 7.7 years, with mortality and cardiovascular events recorded.

Main Results:

  • Higher PTH levels were associated with increased all-cause and cardiovascular mortality.
  • Adjusted analyses confirmed PTH as an independent risk factor for mortality.
  • A strong association was found between PTH levels and sudden cardiac death (SCD).

Conclusions:

  • PTH levels are an independent predictor of mortality and cardiovascular events in patients undergoing coronary angiography.
  • Further research is needed to explore PTH-modifying treatments for cardiovascular risk reduction.
Abstract

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