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Related Concept Videos

Principle of Equivalence01:18

Principle of Equivalence

According to Albert Einstein (1897-1955), free-falling and feeling weightless are intrinsically linked. If a person were in free-fall under gravity, for example, diving towards the Earth from an airplane, they would feel completely weightless. Similarly, a person descending in a lift may feel partially weightless. Broadly speaking, it is assumed that an object in a uniform gravitational field and an object undergoing constant acceleration in the absence of gravity are under the same...
Comparison between RL and RC circuits01:24

Comparison between RL and RC circuits

An RC circuit consists of resistance and capacitance, while in an RL circuit, capacitance is replaced by an inductor. RL and RC circuits are first-order differential circuits that store energy. An RC circuit stores energy in the electric field, while an RL circuit stores energy in the magnetic field. When connected to a battery, an RC circuit charges the capacitor, causing the current to decrease from maximum to zero upon being fully charged. This increases the voltage across the capacitor from...
¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)01:20

¹³C NMR: Distortionless Enhancement by Polarization Transfer (DEPT)

When proton-coupled carbon-13 spectra are simplified by a broadband proton decoupling technique, structural information about the coupled protons is lost. Distortionless enhancement by polarization transfer (DEPT) is a technique that provides information on the number of hydrogens attached to each carbon in a molecule. While the DEPT experiment utilizes complex pulse sequences, the pulse delay and flip angle are specifically manipulated. The resulting signals have different phases depending on...
Stereoisomers02:32

Stereoisomers

On the basis of mirror symmetry, stereoisomers of an organic molecule can be further classified into diastereomers and enantiomers. Diastereomers are stereoisomers that are not mirror images of each other. Substituted alkenes, such as the cis and trans isomers of 2-butene, are diastereomers, as these molecules exhibit different spatial orientations of their constituent atoms, are not mirror images of each other, and do not interconvert. Here, the interconversion is suppressed due to restricted...
Differential Relays01:20

Differential Relays

Differential relays are used to protect generators, buses, and transformers by comparing electrical quantities at different points. When a fault occurs, the difference in current between the two points triggers the relay to operate, opening the circuit breaker. Under normal conditions, the current entering (i1) and leaving (i2) a generator are equal. When a fault occurs, however, these currents become unequal, and the difference current flows in the relay operating coil, causing the relay to...
Prochirality02:05

Prochirality

The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...

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Related Experiment Video

Updated: Jun 13, 2026

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation
07:15

Amide Hydrogen/Deuterium Exchange & MALDI-TOF Mass Spectrometry Analysis of Pak2 Activation

Published on: November 26, 2011

The JARID2-PRC2 duality.

Hans-Martin Herz1, Ali Shilatifard

  • 1Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.

Genes & Development
|May 5, 2010
PubMed
Summary
This summary is machine-generated.

Polycomb group proteins (PcG) regulate development. JARID2 is now identified as a key component of Polycomb-repressive complex 2 (PRC2), enhancing our understanding of PcG's role in cell fate and gene regulation.

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Last Updated: Jun 13, 2026

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Area of Science:

  • Epigenetics
  • Developmental Biology
  • Molecular Biology

Background:

  • Polycomb group proteins (PcG) are crucial for developmental regulation and cell fate.
  • PcG proteins maintain cellular identity through epigenetic mechanisms.

Purpose of the Study:

  • To discuss the recent identification of JARID2 as a component of Polycomb-repressive complex 2 (PRC2).
  • To explore the implications of JARID2's role in PRC2 for understanding PcG function in development.

Main Methods:

  • Literature review of four recent studies identifying JARID2 in PRC2.
  • Analysis of JARID2's function in histone methylation and transcriptional repression.

Main Results:

  • JARID2, a JmjC domain-containing protein, is a component of PRC2.
  • PRC2 mediates histone H3 Lys 27 methylation, a key epigenetic mark for transcriptional repression.
  • JARID2's integration into PRC2 provides new insights into developmental gene silencing.

Conclusions:

  • The identification of JARID2 in PRC2 significantly advances the understanding of Polycomb group protein function.
  • JARID2 plays a critical role in the epigenetic machinery governing developmental processes and cell fate decisions.