Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over time, all...
Depressive Disorders: Etiology01:27

Depressive Disorders: Etiology

Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Antidepressant Drugs: Overview01:25

Antidepressant Drugs: Overview

Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gender discrimination and personal and professional development fostered by allopathic medical schools in the United States.

PloS one·2026
Same author

Annals On Call - Clinical Mastery in Primary Care.

Annals of internal medicine·2026
Same author

Modeling Demand for Direct Patient Contracting Practices: Implications for the Primary Care Workforce.

Journal of general internal medicine·2026
Same author

The Association Between Burnout and Sociodemographic Characteristics with Medical School Attrition.

Journal of general internal medicine·2026
Same author

An academic-legislative partnership for evidence-based policy: the California State Policy Evidence Consortium (CalSPEC).

Evidence & policy : a journal of research, debate and practice·2026
Same author

Advancing Clinical Mastery: An Essential Element of Primary Care Revitalization.

Annals of internal medicine·2026
Same journal

Correction to I.M. Matters News: Sleep medicine for seniors.

Annals of internal medicine·2026
Same journal

Adverse Events After Same-Day COVID-19 and Influenza Vaccination Versus Influenza Vaccination Alone : A Target Trial Emulation.

Annals of internal medicine·2026
Same journal

Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-Like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Methodological Approaches to Real-World Evidence Generation for Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Annals of internal medicine·2026
Same journal

Weekly and Biweekly Treatment With Bofanglutide Versus Semaglutide in Chinese Patients With Type 2 Diabetes : A Phase 2b Randomized Clinical Trial.

Annals of internal medicine·2026
Same journal

Grappling with GLP-1 prescribing.

Annals of internal medicine·2026
See all related articles

Related Experiment Video

Updated: Jun 13, 2026

Animal Models of Depression - Chronic Despair Model (CDM)
05:47

Animal Models of Depression - Chronic Despair Model (CDM)

Published on: September 23, 2021

In the clinic. Depression.

Tonya L Fancher, Richard L Kravitz

    Annals of Internal Medicine
    |May 5, 2010
    PubMed
    Summary
    This summary is machine-generated.

    This clinical overview covers depression prevention, diagnosis, and treatment strategies. It offers CME credits for healthcare professionals seeking to improve patient care and information.

    More Related Videos

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
    04:33

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

    Published on: April 26, 2024

    Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
    04:29

    Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

    Published on: January 7, 2019

    Related Experiment Videos

    Last Updated: Jun 13, 2026

    Animal Models of Depression - Chronic Despair Model (CDM)
    05:47

    Animal Models of Depression - Chronic Despair Model (CDM)

    Published on: September 23, 2021

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
    04:33

    Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

    Published on: April 26, 2024

    Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
    04:29

    Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression

    Published on: January 7, 2019

    Area of Science:

    • Internal Medicine
    • Clinical Psychiatry

    Background:

    • Depression is a prevalent mental health condition requiring comprehensive clinical management.
    • Effective strategies for prevention, diagnosis, and treatment are crucial for patient outcomes.

    Purpose of the Study:

    • To provide a clinical overview of depression.
    • To focus on prevention, diagnosis, treatment, practice improvement, and patient information.

    Main Methods:

    • Content is derived from American College of Physicians (ACP) resources like PIER and MKSAP.
    • Developed by Annals of Internal Medicine editors in collaboration with ACP divisions.
    • Expert review provided by editorial consultants from PIER and MKSAP.

    Main Results:

    • The issue offers a comprehensive clinical overview of depression.
    • It includes practical information for healthcare professionals and patients.
    • Continuing Medical Education (CME) credits are available for readers.

    Conclusions:

    • This resource aims to enhance the clinical practice of managing depression.
    • It emphasizes the importance of evidence-based information for healthcare providers.
    • Accessible via subscription or pay-per-view, with CME opportunities for ACP members.