Related Experiment Video

Updated: Jun 13, 2026

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation
08:43

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Legg-Calve-Perthes disease and risks for cardiovascular diseases and blood diseases

Yasmin D Hailer1, Scott M Montgomery, Anders Ekbom

  • 1Uppsala University Hospital, Department of Orthopaedics, SE-75185 Uppsala, Sweden. yasmin.hailer@surgsci.uu.se

Pediatrics
|May 5, 2010
PubMed

Insights

Patients with Legg-Calvé-Perthes disease (LCPD) face increased risks of cardiovascular and blood diseases, including anemia and coagulation defects. These findings support the role of vascular issues in LCPD pathogenesis.

Area of Science:

  • Orthopedics
  • Cardiology
  • Hematology

Background:

  • Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder of unknown etiology.
  • Previous research suggests potential links between LCPD and vascular pathologies.

Purpose of the Study:

  • To investigate the long-term risks of cardiovascular and blood diseases in patients diagnosed with LCPD.
  • To compare these risks with a matched general population cohort and sibling controls.

Main Methods:

  • A cohort study utilizing the Swedish Inpatient Register identified 3141 patients with LCPD (ages 2-15).
  • A control group of 15,595 individuals without LCPD was randomly selected and matched by birth year, age, gender, and region.
  • Cox proportional-hazard regression analyses, adjusted for socioeconomic index, were employed to estimate relative risks, with sibling comparisons also conducted.

Main Results:

  • LCPD patients exhibited a 1.70-fold increased risk of cardiovascular diseases (HR: 1.70, 95% CI: 1.39-2.09), with higher risk observed in those over 30 at follow-up (HR: 2.10).
  • Significantly elevated risks were found for blood diseases (HR: 1.41, 95% CI: 1.07-1.86), particularly anemias and coagulation defects, which were more pronounced in the >30 age group (HR: 2.70).
  • Higher risks of hypertensive disease (HR: 2.97) and nutritional anemia (HR: 2.92) were also noted in LCPD patients. Sibling analyses confirmed cardiovascular findings.

Conclusions:

  • The study supports the hypothesis that impaired blood supply to the femoral head, due to vascular pathology, plays a role in the development of LCPD.
  • The findings highlight a potential increased lifelong burden of cardiovascular and hematological conditions for individuals with a history of LCPD.
Abstract

More Related Videos

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat04:30

Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat

Published on: February 4, 2021

Related Concept Videos

Cardiovascular System Abnormal Findings I: Inspection and Palpation01:29

Cardiovascular System Abnormal Findings I: Inspection and Palpation

In a cardiovascular examination, inspection and palpation are crucial for identifying abnormalities.
Abnormal findings observed during an inspection
Imaging Studies for Cardiovascular System III: X-Ray01:20

Imaging Studies for Cardiovascular System III: X-Ray

The most common cardiovascular diagnostic test is an X-ray. It produces images of the heart, blood vessels, and adjacent structures.
Definition and Purpose
An X-ray, or radiograph, is a non-invasive method that uses ionizing radiation to take images of internal structures. It is mainly used in cardiac imaging to examine the heart, lungs, and major blood vessels, aiming to identify abnormalities in the heart's size, shape, and position, such as heart failure, congenital defects, and vascular...
Assessment of the Cardiovascular System III: Palpation01:27

Assessment of the Cardiovascular System III: Palpation

Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above the...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...