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Related Concept Videos

Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
Mass Spectrometry: Complex Analysis01:21

Mass Spectrometry: Complex Analysis

Mass spectrometry is an important technique for the identification of pure compounds. However, it has some limitations for the analysis of complex mixtures, often due to excessive fragmentation making the spectrum too complicated to decipher. Mass spectrometry can be combined with suitable separation methods in sequence, forming hyphenated methods, which are useful in the analysis of complex mixtures.
GC–MS is a powerful hyphenated method commonly used in forensics and environmental...
Mass Analyzers: Overview01:13

Mass Analyzers: Overview

The mass analyzer is a crucial component of the mass spectrometer. In the ionization chamber, the vaporized sample is bombarded with a high-energy electron beam to generate a radical cation and further fragment into neutral molecules, radicals, and cations. A series of negatively charged accelerator plates accelerate the cations into the mass analyzer. The mass analyzer separates ions according to their mass-to-charge (m/z) ratios and then directs them to the detector. The common types of mass...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Mass Spectrometry: Overview01:19

Mass Spectrometry: Overview

Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...

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Accelerator mass spectrometry-enabled studies: current status and future prospects.

Ali Arjomand1

  • 1Accium BioSciences, Inc., James Tower Life Sciences, Building, 550 17th Avenue, Suite 550, Seattle, Washington 98122, USA. arjomand@acciumbio.com

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Accelerator mass spectrometry (AMS) offers unparalleled sensitivity for biological and pharmaceutical research. This review highlights AMS applications beyond radiocarbon dating, showcasing its value in drug development and nutrition science.

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Area of Science:

  • Analytical Chemistry
  • Biotechnology
  • Pharmacology

Background:

  • Accelerator mass spectrometry (AMS) is a highly sensitive detection platform.
  • Historically used in archeology for radiocarbon dating.
  • AMS applications in biological and pharmaceutical sciences emerged in the early 1990s.

Purpose of the Study:

  • To provide insight into the diverse applications of AMS.
  • To showcase AMS's problem-solving capabilities in various scientific fields.
  • To review past and future prospects of AMS in research and industry.

Main Methods:

  • Review of existing literature and case studies.
  • Analysis of AMS capabilities in different scientific domains.
  • Examination of study-design strategies utilizing AMS.

Main Results:

  • AMS has demonstrated significant utility in nutrition science, toxicology, and pharmacology.
  • AMS enables novel applications like Phase 0 microdosing in drug development.
  • Recent advancements have established AMS as a valuable pharmaceutical research tool.

Conclusions:

  • AMS technology has evolved from a niche instrument to a versatile tool.
  • Greater awareness and understanding of AMS applications, including study design, are needed.
  • AMS holds significant potential for future advancements in life sciences and drug discovery.