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Control and data acquisition software for high-density CMOS-based microprobe arrays implementing electronic depth

Karsten Seidl¹, Tom Torfs, Patrick A De Mazière

¹Department of Microsystems Engineering (IMTEK), Microsystem Materials Laboratory, University of Freiburg, Georges-Koehler-Allee 103, Freiburg, Germany. seidl@imtek.de

Biomedizinische Technik. Biomedical Engineering

|May 6, 2010

Summary

This summary is machine-generated.

NeuroSelect software offers electronic depth control for cerebral microprobes, improving neural recordings. This system enhances signal quality by electronically selecting optimal electrodes, advancing in vivo neuroscience research.

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Area of Science:

Neuroscience
Biomedical Engineering
Signal Processing

Background:

Extracellular in vivo recordings require precise control of microprobe electrodes.
Current methods rely on mechanical probe translation, limiting flexibility and efficiency.
CMOS-based microprobes offer a high density of switchable electrodes.

Purpose of the Study:

To introduce NeuroSelect software for electronic depth control of cerebral microprobes.
To enable real-time selection of electrodes based on signal quality for improved neural recordings.
To facilitate a closed-loop neural acquisition system.

Main Methods:

Development of NeuroSelect software for managing CMOS-based microprobe hardware.
Implementation of electronic scanning and selection of up to 500 electrodes.
Signal quality assessment using relative spike power and adaptive thresholding for noise estimation.
Manual and semi-automatic electrode selection modes based on signal quality metrics.

Main Results:

NeuroSelect enables electronic depth control, surpassing traditional mechanical methods.
The software facilitates real-time electrode (re)selection for optimal signal acquisition.
Achieved closed-loop control of neural acquisition systems through adaptive electrode management.
Robust spike detection and signal quality assessment for improved data reliability.

Conclusions:

NeuroSelect software significantly advances in vivo neural recording capabilities.
Electronic depth control offers a more efficient and precise alternative to mechanical positioning.
The software supports comprehensive management of neural signal acquisition and analysis.